Used in immunological research to study immune regulation mechanisms, particularly in modulating dendritic cell and monocyte functions. Plays a role in investigating immune tolerance, inflammation, and autoimmune diseases. Commonly applied in protein-protein interaction studies due to its binding affinity with MHC class I molecules. Also utilized in therapeutic development for cancer immunotherapy, where targeting this receptor can influence myeloid-derived suppressor cell activity. The Fc tag enables easy detection and purification, making it valuable in assay development and antibody-based binding experiments.