Used in cell culture applications to maintain pluripotency of stem cells, particularly in human embryonic stem cells and induced pluripotent stem cells. Supports self-renewal by activating signaling pathways such as JAK-STAT through binding to the LIF receptor. The Fc tag enhances solubility and allows for easy detection and purification, making it suitable for research in regenerative medicine and developmental biology. Commonly used in studies involving stem cell expansion, differentiation inhibition, and cellular reprogramming.