Used in research to study cell signaling pathways, particularly the Notch signaling pathway, which plays a critical role in cell differentiation, development, and tissue homeostasis. The Fc tag allows for easy detection and purification, making it useful in protein-protein interaction studies, immunoassays, and binding assays. Commonly applied in immunology and cancer research to investigate the role of JAG1 in tumor progression, angiogenesis, and immune regulation. Also employed as a capture or detection reagent in ELISA and flow cytometry applications.