Used in immunological research to study cell adhesion and signaling processes involving integrin β7, particularly in lymphocyte homing and gut-specific immune responses. The Fc tag enables easy detection and purification, making it valuable in binding assays, protein-protein interaction studies, and development of therapeutic antibodies targeting inflammatory bowel diseases and other immune disorders. Also employed in ELISA, flow cytometry, and surface plasmon resonance (SPR) to analyze interactions with ligands such as MAdCAM-1, VCAM-1, and E-cadherin.