Used in research and development for studying interleukin-6 signaling pathways involved in inflammation, autoimmune diseases, and cancer. Serves as a capture or detection antigen in immunoassays such as ELISA to measure anti-IL-6R antibodies or to screen therapeutic agents targeting the IL-6 receptor. Employed in protein-protein interaction studies to analyze binding with IL-6 and gp130 components. Facilitates the development and characterization of monoclonal antibodies and biosimilars aimed at modulating IL-6 receptor activity. The His tag allows for easy purification and detection using nickel-based affinity systems, making it suitable for in vitro studies and diagnostic applications.