Used in research and drug development targeting immune system disorders. Plays a key role in studying cell adhesion processes, particularly in inflammation and autoimmune diseases such as multiple sclerosis and asthma. Facilitates binding studies with therapeutic antibodies and small molecules due to its His tag, enabling purification and detection in assays. Supports development of inhibitors that block integrin-mediated leukocyte migration. Widely applied in ELISA, surface plasmon resonance, and cellular binding experiments to evaluate drug candidates.