Used in research to study cell-matrix interactions, particularly in collagen binding and signaling. Plays a role in understanding tumor progression, fibrosis, and wound healing due to its involvement in cell adhesion and migration. This protein is a key tool for investigating the role of integrins in smooth muscle cells and fibroblasts, especially in collagen-producing tissues such as skin, lungs, and heart.

The His tag enables efficient purification using Ni-NTA resin and facilitates detection in experimental settings, making it valuable for protein production in ELISA, immunoassays, or ligand binding studies. Its use in in vitro systems aids in elucidating mechanisms of tissue remodeling diseases like fibrosis and cancer, as well as validating therapeutic targets for integrin-based drugs to regulate cell proliferation or chronic inflammation.