Used in immunological research to study eosinophil activation, differentiation, and survival. Plays a key role in models of allergic inflammation and asthma due to its involvement in eosinophil-mediated responses. The His Tag allows for easy purification and detection, making it valuable in protein binding assays, receptor studies, and development of anti-eosinophil therapeutics. Commonly used in cell culture to stimulate eosinophil colonies and in ELISA or Western blot as a reference standard.