Used in research and drug development targeting integrin-mediated cellular processes. Plays a key role in studies of cell adhesion, migration, and signaling, particularly in cancer, inflammation, and angiogenesis. The His Tag allows for easy purification and detection, making it valuable in protein interaction assays and high-throughput screening for therapeutic agents. Commonly used in ELISA, Western blot, and surface plasmon resonance (SPR) to analyze ligand binding and antibody interactions.