Used in research and development of therapeutics targeting inflammatory diseases and immune disorders. Plays a key role in cell adhesion and migration, making it valuable for studying autoimmune conditions such as multiple sclerosis, asthma, and inflammatory bowel disease. The Fc tag enables easy detection and purification, and supports use in assays involving immune cell binding and inhibition studies. Also employed in the development of monoclonal antibodies and biologics aimed at blocking integrin-mediated interactions.