Used in research to study the IL-31 signaling pathway involved in inflammatory and pruritic (itch) skin conditions such as atopic dermatitis. Acts as a soluble receptor that binds IL-31, helping to block its interaction with the cell surface receptor, thereby serving as a tool to investigate potential therapeutic mechanisms for itch and allergic skin diseases. Also employed in protein-protein interaction studies and immunoassay development due to its Fc-mediated detection and purification capabilities.