Used in immunological research to study the role of IL-23 receptor signaling in T-cell differentiation and inflammatory responses. Employed in protein-protein interaction studies, particularly in binding assays with IL-23 ligand. Serves as a target in drug development for autoimmune diseases such as psoriasis, inflammatory bowel disease, and multiple sclerosis. The His tag facilitates purification and detection in recombinant expression systems. Commonly used in ELISA, surface plasmon resonance, and flow cytometry applications to evaluate therapeutic antibodies and inhibitors.