Used in immunological research to study interleukin-18 signaling pathways. Binds specifically to IL-18, enabling investigation of inflammatory responses and immune cell activation. Commonly employed in protein-protein interaction studies, ELISA, and receptor-ligand binding assays. The His tag allows for easy purification and detection, making it suitable for recombinant expression systems. Plays a role in developing assays for autoimmune diseases and cancer immunotherapy research.