Used in immunological research to study the IL-13 signaling pathway, particularly in diseases involving allergic responses and asthma. The Fc tag enables easy detection and purification, making it valuable in binding assays and protein interaction studies. Commonly employed in ELISA, flow cytometry, and surface plasmon resonance to analyze ligand-receptor interactions. Also serves as a tool in developing neutralizing antibodies and therapeutic inhibitors targeting IL-13 receptor activity in inflammatory and autoimmune conditions.