Used in research to study the IL-22 signaling pathway, which plays a key role in immune responses and tissue repair. Acts as a soluble receptor that can bind IL-22, making it useful for neutralizing IL-22 activity in experimental models. Commonly employed in assays to detect IL-22 or block its interaction with cell surface receptors. Helps in understanding inflammatory diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Also used in protein-protein interaction studies and as a control in immunoassays due to the Fc tag, which allows for easy detection and purification.