Used in research to study the IL-22 signaling pathway, which plays a key role in immune responses and inflammation. Binds to interleukin-22 (IL-22) and is utilized in protein interaction studies, receptor-ligand binding assays, and immunoassays. The His tag allows for easy purification and detection, making it valuable in recombinant protein workflows. Commonly used in studies related to autoimmune diseases, tissue repair, and host defense mechanisms at barrier surfaces such as skin and gut.