Used in immunological research to study the role of IL-13 signaling in inflammatory diseases, particularly asthma and allergic responses. Serves as a capture antigen in ELISA and other immunoassays for detecting anti-IL-13Ra2 antibodies or measuring ligand binding affinity. Employed in protein-protein interaction studies due to its ability to bind IL-13 with high affinity. The His tag facilitates purification and detection in recombinant expression systems. Investigated as a potential target in cancer immunotherapy, especially in glioblastoma, where IL-13Ra2 is overexpressed on tumor cells. Supports development of monoclonal antibodies and chimeric antigen receptor (CAR) T-cell therapies targeting IL-13Ra2-positive tumors.