Used in research and development for studying the c-Met signaling pathway, which plays a key role in cell growth, survival, and motility. Commonly applied in protein-protein interaction studies, especially in cancer research where c-Met dysregulation is linked to tumor progression and metastasis. Serves as a target for screening and evaluating potential inhibitors in drug discovery. The His tag facilitates easy purification and detection, making it suitable for use in ELISA, Western blot, and surface plasmon resonance assays. Also employed in structural studies to understand ligand binding and receptor activation mechanisms.