Used in research to study the Wnt signaling pathway and its role in stem cell regulation, tissue development, and cancer progression. The Fc tag enables easy detection and purification, making it valuable in protein-protein interaction studies and immunoassays. Commonly applied in ELISA, Western blot, and flow cytometry to investigate receptor-ligand binding and signal transduction mechanisms. Also supports drug discovery efforts targeting GPR48-related diseases such as metabolic disorders and bone development conditions.