Used in research to study the role of GPNMB in immune regulation and cancer progression. The Fc tag allows for easier detection and purification, making it useful in immunoassays and protein interaction studies. Commonly applied in ELISA, Western blot, and flow cytometry to investigate binding properties and antibody interactions. Also employed in therapeutic development for targeting GPNMB-expressing tumors, such as melanoma and glioblastoma. Supports the development of monoclonal antibodies and biomarker validation in inflammatory and neurodegenerative diseases.