Used in cancer research, particularly for hepatocellular carcinoma (HCC) and other GPC3-expressing tumors. Serves as a recombinant protein for developing and testing targeted therapies, including monoclonal antibodies and CAR-T cells. Commonly used in immunoassays, binding studies, and functional assays to evaluate drug candidates targeting the GPC3 pathway. The Fc tag enhances detection and purification capabilities, making it suitable for in vitro and in vivo applications in oncology and immunology research.