Used in immunological research to study red blood cell membrane proteins and their role in cell adhesion and signaling. Serves as a capture antigen in ELISA and other immunoassays for detecting anti-glycophorin antibodies. Employed in protein-protein interaction studies due to the Fc tag, enabling easy detection and purification with anti-Fc antibodies. Supports development of monoclonal antibodies targeting CD235a for diagnostic applications in hematology. Also utilized in flow cytometry and Western blotting as a positive control.