Used in immunological research to study neutrophil-mediated immune responses, particularly in antibody-dependent cellular cytotoxicity (ADCC) and immune complex clearance. Serves as a binding target for therapeutic monoclonal antibodies to evaluate Fc engineering effects on effector functions. Applied in ELISA and surface plasmon resonance (SPR) assays to measure antibody affinity and specificity. Supports development of biologics by enabling characterization of Fc gamma receptor interactions in innate immunity.