Used in immunological research to study Fc gamma receptor-mediated signaling, particularly in immune cell activation and antibody-dependent cellular phagocytosis. Employed in binding assays to evaluate therapeutic monoclonal antibodies' affinity and efficacy. Serves as a critical tool in characterizing antibody isotypes and their interactions with immune effector cells. Commonly applied in drug development for autoimmune diseases, cancer immunotherapy, and vaccine design. The His tag facilitates easy purification and detection in recombinant protein studies.