Used in research to study Wnt signaling pathways, particularly in cancer development and stem cell regulation. Binds specifically to Wnt ligands and is employed in protein interaction studies, immunoassays, and receptor-ligand binding experiments. The Fc tag enables easy detection and purification using anti-Fc antibodies or protein A/G systems. Commonly used in ELISA, flow cytometry, and functional studies to investigate the role of FZD10 in diseases like synovial sarcoma and other malignancies.