Used in research and development of targeted cancer therapies, particularly for cancers that overexpress the folate receptor alpha (FOLR1), such as ovarian, lung, and breast cancers. The His tag facilitates purification and detection, making it valuable in immunoassays, protein-protein interaction studies, and antibody development. It serves as an antigen for generating anti-FOLR1 antibodies and is employed in the validation of diagnostic tools and therapeutic agents aimed at folate receptor pathways.