Used in immunological research to study ectonucleotide pyrophosphatase/phosphodiesterase family functions, particularly in immune cell signaling and regulation. Serves as a detection tool in flow cytometry and ELISA assays due to the Fc tag enabling easy binding with secondary antibodies. Plays a role in biomarker validation for allergic responses and mast cell activation. Supports development of therapeutic antibodies by acting as a recombinant antigen for antibody screening and characterization. Also utilized in protein-protein interaction studies involving CD203c receptors and ligands in hematopoietic cells.