Used in biomedical research to study inflammatory responses and immune regulation. Functions as a signaling molecule in cellular communication, particularly in modulating endothelial cell activity. Employed in assays to investigate angiogenesis and vascular permeability. The His Tag allows for easy detection and purification using nickel-based affinity systems, making it valuable in protein expression and isolation workflows. Commonly utilized in ELISA, Western blotting, and immunoprecipitation experiments to understand protein-protein interactions and signaling pathways involved in inflammation and cancer progression.