Used in research and development for studying autoimmune diseases such as pemphigus vulgaris, where DSG3 (desmoglein 3) is a primary target of pathogenic antibodies. The Fc tag enables easy detection and purification, making it valuable in immunoassays, antibody binding studies, and therapeutic antibody screening. It is also employed in ELISA and surface plasmon resonance (SPR) to analyze antibody affinity and kinetics. Due to its role in cell adhesion, it supports investigations into epithelial tissue integrity and blistering skin disorders.