Used in research and development of therapeutics targeting the Notch signaling pathway, particularly in oncology. Plays a role in studying cell differentiation and development due to its involvement in neural and tumor cell regulation. Commonly employed in protein-protein interaction studies, immunoassays, and as a capture antigen in antibody screening. The Fc tag facilitates detection, purification, and enhances protein stability in experimental systems. Supports the development of monoclonal antibodies and bi-specific molecules for cancer immunotherapy, especially in small cell lung cancer and other neuroendocrine tumors.