Used in research and development for studying RET receptor signaling pathways involved in cell growth and differentiation. Commonly applied in immunoassays and protein interaction studies due to the Fc tag, which allows for easy detection and purification. Plays a role in cancer research, particularly in cancers linked to RET mutations or rearrangements, such as thyroid and lung cancers. Supports the development and testing of targeted therapies, including monoclonal antibodies and small molecule inhibitors, by serving as a binding target in functional assays.