Used in immunological research to study macrophage differentiation, survival, and activation. Supports the growth and maintenance of monocyte/macrophage lineage cells in cell culture. Employed in cancer research to investigate tumor-associated macrophages and their role in tumor progression and immune evasion. Applied in bone biology studies due to its role in osteoclast formation and function. Utilized in therapeutic development for modulating immune responses and exploring treatments for inflammatory diseases, bone disorders, and certain cancers. Also suitable for antibody development and testing the efficacy of specific inhibitors targeting M-CSF signaling pathways. The His tag facilitates easy purification and detection in experimental systems.