Used in immunological research to study cell signaling and immune responses. Plays a role in the recruitment and activation of immune cells such as monocytes, natural killer cells, and T cells. Applied in studies of inflammatory diseases, including atherosclerosis, rheumatoid arthritis, and neuroinflammation. Utilized in protein-protein interaction assays and receptor binding studies due to its interaction with CX3CR1 receptor. The His tag facilitates purification and detection in experimental settings, making it valuable in assay development and therapeutic target validation.