Used in immunological research to study granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathways. Serves as a capture or detection target in ELISA and other binding assays to measure GM-CSF activity or anti-GM-CSF antibodies. Employed in protein-protein interaction studies to understand receptor-ligand binding kinetics. Supports development of therapeutic antibodies targeting the GM-CSFRα pathway, particularly in inflammatory diseases like rheumatoid arthritis and multiple sclerosis. The His tag enables easy purification and immobilization on nickel-based surfaces for biosensor applications or surface plasmon resonance (SPR) analysis.