Used in immunological research to study granulocyte-macrophage colony-stimulating factor receptor signaling. Supports the differentiation and proliferation of hematopoietic cells in cell culture systems. Employed in assays to evaluate immune cell activation, particularly of monocytes, eosinophils, and dendritic cells. The Fc tag enables easy detection and purification, and can facilitate in vivo half-life extension when used in animal models. Investigated in therapeutic development for immune modulation and vaccine adjuvancy.