Used in cancer research, particularly in studying tumor angiogenesis. Plays a role in the development of endothelial cells and is involved in the formation of blood vessels in tumors. Often utilized in immunoassays and protein interaction studies due to the Fc tag, which allows for easy detection and purification. Supports the development of targeted therapies by helping identify specific markers in tumor vasculature. Also used as a capture or detection reagent in ELISA and flow cytometry applications.