Used in research to study cell adhesion mechanisms involved in tissue development and cancer progression. Plays a role in osteoblast differentiation, making it valuable for bone formation and regeneration studies. Applied in immunological assays to detect interactions between cadherins and immune cells. Utilized in protein-protein interaction studies due to the Fc tag, which allows easy detection and purification. Investigated in autoimmune diseases like rheumatoid arthritis for its involvement in synovial tissue organization. Also employed as a therapeutic target candidate in fibrosis and metastatic cancers.