Used in research to study gastrointestinal cancers, particularly colorectal and hepatocellular carcinomas, due to its overexpression in tumor tissues. Serves as a potential biomarker for cancer diagnosis and prognosis. The His tag enables easy purification and detection, making it valuable in immunoassays, protein-protein interaction studies, and antibody development. Also utilized in drug screening platforms targeting cadherin-mediated signaling pathways.