Used in immunological research to study T cell activation and signaling pathways. The His tag enables efficient purification of the recombinant CD38 protein via nickel affinity chromatography, facilitating its use in immunoassays and detection applications, including those targeting CD38-expressing cells or anti-CD38 antibodies.

Employed in drug development for targeting CD38 in hematological malignancies like multiple myeloma, including the development of therapeutic antibodies.

Supports structural and functional studies of CD38 enzyme activity, including its role in metabolizing NAD+ and regulating intracellular calcium levels.

Enables protein-protein interaction studies on immune cell surfaces and serves as a reagent or biomarker in flow cytometry and ELISA applications.