Used in immunological research to study macrophage activation and function, particularly in inflammation and immune regulation. The His tag allows for easy purification and detection in protein expression systems. Commonly employed in ELISA, Western blotting, and protein-protein interaction studies to investigate scavenger receptor biology and its role in diseases like sepsis, atherosclerosis, and neurodegenerative disorders. Also utilized in the development of diagnostic assays and therapeutic targets due to its involvement in hemoglobin clearance and anti-inflammatory responses.