Used in immunological research to study macrophage function and inflammatory responses. Binds specifically to CD163 ligands, enabling detection and quantification in assays like ELISA, flow cytometry, and immunoprecipitation. Facilitates the study of hemoglobin-haptoglobin complex clearance due to its role in scavenging. The Fc tag allows for easy detection with anti-Fc secondary antibodies and can be used in therapeutic development targeting anti-inflammatory pathways. Also employed as a capture or detection reagent in biomarker studies related to sepsis, hemolysis, and autoimmune diseases.