Used in research and development for cancer diagnostics and therapy due to its high expression in hypoxic tumor cells, particularly in renal cell carcinoma and other solid tumors. Serves as a biomarker for tumor hypoxia and is involved in studies targeting pH regulation in the tumor microenvironment. The His Tag facilitates purification and detection, making it valuable in immunoassay development, antibody screening, and structural studies aimed at designing inhibitors for cancer treatment.