Used in immunological research to study immune checkpoint pathways. Facilitates protein-protein interaction studies due to the His tag, enabling easy purification and detection. Employed in binding assays to analyze interactions with ligands like HVEM (herpesvirus entry mediator). Supports development of therapeutic antibodies and inhibitors targeting the BTLA pathway for cancer immunotherapy and autoimmune diseases. Commonly used in ELISA, Western blotting, and surface plasmon resonance (SPR) experiments.