Used in immunological research to study the role of B7-H3 (CD276) in immune regulation, particularly in cancer immunotherapy. Acts as a ligand for receptors on T cells, helping to modulate immune responses. Employed in binding assays and protein interaction studies to screen potential therapeutic antibodies or inhibitors. Commonly used in ELISA, surface plasmon resonance (SPR), and flow cytometry to evaluate molecular interactions. Supports development of checkpoint inhibitors and targeted biologics due to its involvement in immune evasion by tumor cells.