Used in research and development of targeted cancer therapies, particularly in studies involving tumor progression and metastasis. The His tag enables facile purification using immobilized metal affinity chromatography (IMAC) and detection with anti-His tag antibodies. Plays a role in immunoassay development and antibody screening due to its extracellular domain presentation. Supports investigation of AXL receptor signaling pathways in diseases like leukemia, breast cancer, and lung cancer, as well as in inflammation and viral infections such as Dengue and Zika. Commonly applied in protein-protein interaction studies and as a capture antigen in ELISA and biosensor applications. Facilitates the evaluation of therapeutic antibodies and small molecule inhibitors targeting the AXL kinase pathway.