Used in research and development of therapeutics targeting angiogenesis and vascular stability. Plays a role in studying diseases involving blood vessel formation such as cancer, diabetic retinopathy, and inflammatory disorders. The Fc tag enables easier detection, purification, and prolonged half-life in biological assays. Commonly used in protein-protein interaction studies, immunoassays, and as a control in antibody development. Supports investigation of signaling pathways related to endothelial cell function and vascular permeability.