Used in neuroscience research to study Parkinson’s disease and other synucleinopathies. Serves as a model protein for investigating protein aggregation, misfolding, and fibril formation. The His tag facilitates purification and detection in immunoassays and pull-down experiments. Employed in drug screening to identify compounds that inhibit alpha-synuclein aggregation. Also used to generate antibodies and in structural studies such as NMR and X-ray crystallography.