Used in immunological research to study cell adhesion and signaling processes involved in immune responses, cancer progression, and stem cell interactions. Facilitates the development of binding assays and protein-protein interaction studies due to its fusion with the Fc tag, which allows easy detection and purification. Employed in therapeutic antibody development and target validation, particularly in oncology and regenerative medicine. Supports cell-based assays by promoting cell-cell adhesion in vitro, useful for investigating tumor metastasis and immune cell trafficking.