Used in immunological research to study T-cell activation and inflammatory responses in non-human primate models. Supports the development and testing of biologics, especially those targeting the TNF pathway, due to its structural similarity to human TNFα. Commonly employed in in vitro assays to evaluate drug efficacy, cytotoxicity, and signaling pathways. The His tag facilitates easy detection and purification, making it suitable for protein-protein interaction studies and antibody binding assays.