Used in preclinical research to study the function and targeting of TROP2, a transmembrane glycoprotein overexpressed in various cancers. The Fc tag enables detection, purification, and potential assessment of antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC) in immunotherapy development. Commonly employed in binding assays, pharmacokinetic studies, and evaluation of therapeutic antibodies in non-human primate models due to its relevance in translational oncology.